Cybersecurity Resources for Exascale and Beyond
Securing HPC, AI/ML, and next-generation computing environments
From high-performance computing (HPC) systems to AI/ML and data-intensive platforms, advanced computing environments are driving breakthroughs across science, defense, and national security. As these systems grow in scale and complexity, they also introduce new and evolving cybersecurity challenges.
This hub brings together ShorePoint’s expertise alongside curated third-party resources and industry events to help federal agencies better understand and secure advanced computing environments. The content will continue to expand with new insights, resources, and engagement opportunities.
HPC Terms and Acronyms | Industry Resources | Upcoming Events
How Can We Help
ShorePoint supports federal agencies, labs, and research institutions in securing advanced computing environments, from HPC systems to AI/ML and data-intensive platforms. Our approach combines mission-focused cybersecurity with deep domain expertise to address the unique challenges of these complex environments.
HPC Terms and Acronyms
Core terminology and reference materials to build a shared understanding of advanced computing security concepts.
HPC Terms and Acronyms: A Federal Ecosystem Guide
High-performance computing (HPC) sits at the center of some of the most ambitious scientific and national security efforts underway today. As HPC environments grow in scale and importance, so does the specialized language used to describe them. This guide provides a reference to many of the key terms shaping the federal HPC landscape.
HPC Terms & Acronyms: A Genesis Mission Reference
The Genesis Mission represents a major effort to integrate supercomputers, AI systems, and scientific data across the federal research landscape. This guide provides a quick reference to key terms and acronyms shaping the high-performance computing (HPC) ecosystem behind the Genesis Mission.
Industry Resources
A curated selection of government, industry, and research resources to deepen understanding of the evolving threat and technology landscape for HPCs and other advanced computing systems.
A National Mission to Accelerate Science Through Artificial Intelligence
A national initiative launched by executive order in November 2025, directing the DOE to harness AI, supercomputing, and quantum systems across the 17 national laboratories to accelerate scientific discovery through artificial intelligence, with a stated goal of doubling U.S. research productivity within 10 years.
NIST | AI Risk Management Framework
Led by the Information Technology Laboratory (ITL) AI Program, and in collaboration with the private and public sectors, NIST has developed a framework to better manage risks to individuals, organizations, and society associated with artificial intelligence.
NIST | HPC Security Working Group
The NIST High-Performance Computing (HPC) Security Working Group brings together government, industry, and academic experts to develop practical guidance and standards for securing modern HPC environments. Its work focuses on addressing the unique risks of large-scale, multi-tenant, and high-speed computing systems that underpin critical research, national security, and advanced innovation.
High-Performance Computing Security: Architecture, Threat Analysis, and Security Posture
A NIST special publication establishing a four-zone HPC reference architecture (Access, Management, Computing, and Data Storage zones), along with threat analysis and security guidance tailored to HPC environments.
High-Performance Computing (HPC) Security Overlay (Initial public draft)
A companion to SP 800-223 that provides an actionable HPC security control overlay built on the NIST SP 800-53 moderate baseline, tailoring 60 security controls with HPC-specific supplemental guidance.
A global community-driven and expert-led initiative to create freely available open-source guidance and resources for understanding and mitigating security and safety concerns for Generative AI applications and adoption.
Semiannual Ranking of the World’s Fastest Supercomputers
Upcoming Events
Opportunities to connect with ShorePoint experts and stay current on developments in advanced computing and cybersecurity.
May 4–7, 2026 | Federal Business Council’s NLIT Summit 2026
The NLIT Summit is sponsored by the NLIT Society, a professional society founded to facilitate the exchange of best practices and ideas among IT and Cybersecurity professionals within the DOE complex, strengthen the infrastructure, and identify efficiencies within the DOE laboratory system.
ShorePoint’s Director of Advanced Computing Solutions,, Ian Lee, is a speaker at this educational session:
Wednesday, May 6: 1:20 PM – 1:50 PM CDT
Unlocking Classified Data with Trusted AI: Zero‑Trust Fabrics, RAG, and Federated Learning
Room 2210
The national laboratory community faces a unique challenge: how to harness transformational AI capabilities while operating under the most stringent security requirements in the civilian government. Traditional approaches—complete air-gapping or centralized cloud architectures—fail to meet the dual imperatives of mission acceleration and data sovereignty. This panel explores emerging architectural patterns that enable secure, composable AI ecosystems purpose-built for classified environments.
Panelists will present the “Genesis paradigm”: a three-tier architecture separating systems of record (legacy HPC and experimental data), a governed knowledge layer (semantic enrichment with attribute-based access control), and modular AI compute (general-purpose LLMs, domain-specific physics models, and quantum-classical hybrid systems). Discussion topics include operationalizing zero-trust principles at the data object level rather than network perimeter, implementing immutable provenance for model certification, practical approaches to prompt injection defenses, weight-sharing across federated learning environments, zero-trust data fabrics using technologies like Trusted Data Format (TDF), policy-as-code enforcement through platforms like Cloudera’s SDX, and structuring public-private partnerships that accelerate innovation without creating vendor lock-in or foreign dependency.
Attendees will gain insight into how DOE labs can move from manual, keyword-based data discovery to natural language, agentic search across decades of classified archives—while ensuring that unauthorized users cannot even infer the existence of compartmented datasets through query
ShorePoint role: Attend, Speak
Sept. 9–10, 2026 | HPC User Forum Fall 2026
The HPC User Forum was established in 1999 to promote the health of the global HPC industry and address issues of common concern to users.
ShorePoint role: Attend
Nov. 15–20, 2026 | Supercomputing 26 (SC26)
SC26 is where the HPC community comes together to make technological and research progress, enlighten and empower all people, eliminate barriers to opportunities, chart the course for computing’s impact in the world — and have fun doing it.
ShorePoint role: Attend
April 5–9, 2027 | HPC Security Technical Exchange (STX) 2027
A first-of-its-kind event to bring together experts, practitioners, and enthusiasts in government HPC cybersecurity to share insights, discuss challenges, and explore innovative solutions.
ShorePoint role: Host, Ian Lee is founder and chair
Connect with Our Team
Have questions about securing advanced computing environments? ShorePoint works with federal agencies to navigate evolving cybersecurity challenges across HPC, AI/ML, and data-intensive platforms.